Studies on the control of gluconeogenesis in sheep: effect of propionate, casein and butyrate infusions.
نویسندگان
چکیده
Page 170, last paragraph should read: ‘Bergman (1964) suggested that the rate of utilization of glucose in sheep is a function of plasma glucose concentration. This is only indicated in the present study with sheep given glucose infusions (equations 3 and 4). From an examination of values recorded by the authors with forty-four sheep on a wide variety of diets, including the present results, no significant relationship ( P > 0.05) was fourd between plasma glucose concentration (over a range 500-900 mg/l) and the irreversible loss of [14C]glucose from plasma ( Yp) (which varied from 30 to 90 mg/min) (r = 0.159, n = 66) or Yp/W0.55 (r = 0.107, n = 66) where Wis the live weight of the animal. I t is possible that if individual animals were examined a relationship may exist, and this would explain the relationship when fed and starved sheep are grouped, sincc thesame animals are generally used as is evident in the relationship found by Bergman (1964). That is, individual sheep may control their plasma glucose concentration within narrow limits.’
منابع مشابه
Uptake and metabolism of propionate in the liver isolated from sheep treated with glucagon.
The uptake and metabolism of propionate in the isolated perfused caudal lobe of the liver and in isolated hepatocytes were examined following treatment of sheep with glucagon or saline. Glucagon or sterile saline was infused at 9.8 micrograms/min for 3 h into the jugular vein and then the caudal lobe of the liver was removed surgically under anaesthesia. The caudal lobe was used either to prepa...
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The possibility that butyrate may be glucogenic in ruminants has been suggested by several experimental studies. Intravenous injection of butyrate in sheep was followed by increased concentrations of blood sugar (1) and, in lambs, it was found that butyrate was more effective than propionate for alleviating insulin-induced hypoglycemia (2) ; acetate injection did not have a similar effect in ei...
متن کاملPyruvate and propionate metabolism in lactating cows. Effect of butyrate on pyruvate metabolism.
The glucogenic behavior of butyrate in ruminants has been reported frequently, but the metabolic nature of this anomalous relationship has remained obscure. To test the possibility that the metabolism of butyrate affects gluconeogenesis, lactating cows were given intravenous injections of tracer amounts of pyruvate-2-14C and, in parallel experiments, of pyruvate-2-l% plus substrate amounts of s...
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Feeding and postruminal infusion of propionate is known to increase N retention in ruminants. Our aim was to determine the role of rumen propionate on urea N recycling and gluconeogenesis in growing sheep. In Exp. 1, wether sheep ( = 6; 32.5 ± 3.57 kg BW) fitted with a rumen cannula were fed to 1.8 × ME requirement a concentrate-type ration (172 g CP/kg DM and 10.4 MJ ME/kg DM) and continuously...
متن کاملEffect of insulin on the utilization of propionate in gluconeogenesis in sheep.
The effects of insulin on the utilization of propionate in glucose synthesis were studied in fed and fasted sheep. Insulin was infused at 0.40 microU/h into the mesenteric vein. Glucose was infused to prevent hypoglycaemia. The rate of incorporation of [2-14C]propionate into glucose was determined before and during insulin infusion. After 150 min of insulin infusion endogenous glucose synthesis...
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عنوان ژورنال:
- The British journal of nutrition
دوره 29 2 شماره
صفحات -
تاریخ انتشار 1973